The androgen receptor amino-terminal domain: structure, function and therapeutic potential

The androgen receptor amino-terminal domain: structure, function and therapeutic potential

Blog Article

Signalling by the steroid hormone testosterone involves the androgen receptor (AR), a structurally dynamic protein.The amino-terminal domain of the AR makes up more than half of the protein and has been Vinegar Dispensers found to be intrinsically disordered.This structural plasticity mediates receptor-dependent transcription, intradomain interactions and allosteric regulation.AR activity is a primary drug target in advanced Backpacks and metastatic prostate cancer, a leading cause of cancer-related death in men.Recent research has focused on the amino-terminal domain as a novel drug target.

In this review, we discuss the structural properties of the receptor and highlight some promising preclinical and clinical studies that aim to develop a drug discovery pipeline of small-molecule inhibitors targeting the amino-terminal domain.